Treatment of Ocular Surface Squamous Neoplasia with Interferon Alpha-2b

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Topical Interferon Alpha-2b for Treatment of Noninvasive Ocular Surface Squamous Neoplasia with 360° Limbal Involvement

PURPOSE To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement. METHODS In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Out...

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Ocular surface squamous neoplasia treated with topical interferon α 2b.

To cite: Pujari A. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016218344 DESCRIPTION A 64-year-old male patient presented with fleshy lesion over the right temporal conjunctiva for the past 3 months with a gradual increase in size. History of trauma and pain was absent, and past history did not reveal any significant ocular/systemic morbidities. Right eye exa...

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Topical interferon alpha 2b eye-drops for treatment of ocular surface squamous neoplasia: a dose comparison study.

BACKGROUND/AIMS To compare the effectiveness and side-effect profile of two doses of interferon alpha2b (IFNalpha2b) eye-drops (1 million international units (IU)/ml versus 3 million IU/ml) in the treatment of ocular surface squamous neoplasia (OSSN). METHODS Retrospective case series. RESULTS Thirty-five eyes were identified over an 11-year period (1996-2007). Twenty-one eyes (19 patients) wit...

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Ocular Surface Squamous Neoplasia

The ocular surface is composed of the conjunctiva and the cornea. The conjunctiva is a mucous membrane which covers the globe and inner part of the eyelids. The morphology of conjunctival epithelial cells are nonkeratinized stratified epithelia which vary from cuboidal over the tarsus, to columnar in the fornices, to squamous epithelia on the globe. Goblet cells account for up to 10% of the bas...

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Treatment of ocular surface squamous neoplasia with Mitomycin C.

AIM To report the outcome of treatment of non-invasive ocular surface squamous neoplasia (or conjunctival-corneal intra-epithelial neoplasia (CCIN)) where topical mitomycin C (MMC) has been used in the treatment regimen. DESIGN Prospective, non-comparative interventional case series. PARTICIPANTS 91 primary or recurrent CCIN lesions from 90 patients treated in a single ocular oncology centre ov...

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ژورنال

عنوان ژورنال: Pakistan Journal of Ophthalmology

سال: 2020

ISSN: 0886-3067

DOI: 10.36351/pjo.v35i4.939